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is not yet present. The // classes are added to so styling immediately reflects the current // toolbar state. The classes are removed after the toolbar completes // initialization. const classesToAdd = ['toolbar-loading', 'toolbar-anti-flicker']; if (toolbarState) { const { orientation, hasActiveTab, isFixed, activeTray, activeTabId, isOriented, userButtonMinWidth } = toolbarState; classesToAdd.push( orientation ? `toolbar-` + orientation + `` : 'toolbar-horizontal', ); if (hasActiveTab !== false) { classesToAdd.push('toolbar-tray-open'); } if (isFixed) { classesToAdd.push('toolbar-fixed'); } if (isOriented) { classesToAdd.push('toolbar-oriented'); } if (activeTray) { // These styles are added so the active tab/tray styles are present // immediately instead of "flickering" on as the toolbar initializes. In // instances where a tray is lazy loaded, these styles facilitate the // lazy loaded tray appearing gracefully and without reflow. const styleContent = ` .toolbar-loading #` + activeTabId + ` { background-image: linear-gradient(rgba(255, 255, 255, 0.25) 20%, transparent 200%); } .toolbar-loading #` + activeTabId + `-tray { display: block; box-shadow: -1px 0 5px 2px rgb(0 0 0 / 33%); border-right: 1px solid #aaa; background-color: #f5f5f5; z-index: 0; } .toolbar-loading.toolbar-vertical.toolbar-tray-open #` + activeTabId + `-tray { width: 15rem; height: 100vh; } .toolbar-loading.toolbar-horizontal :not(#` + activeTray + `) > .toolbar-lining {opacity: 0}`; const style = document.createElement('style'); style.textContent = styleContent; style.setAttribute('data-toolbar-anti-flicker-loading', true); document.querySelector('head').appendChild(style); if (userButtonMinWidth) { const userButtonStyle = document.createElement('style'); userButtonStyle.textContent = `#toolbar-item-user {min-width: ` + userButtonMinWidth +`px;}` document.querySelector('head').appendChild(userButtonStyle); } } } document.querySelector('html').classList.add(...classesToAdd); })(); Anding Shen | ÃÛÌÒapp

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Dr. Anding Shen

Professor
Biology

Biography

Dr. Shen has ongoing research studying latent reservoirs of HIV infection. She is investigating the mechanisms of how the reservoirs are formed and potential ways to remove the latent reservoir. Her newest work involves the role of Endothelial cells in HIV latent reservoir in T cells.

Dr. Shen is a member of the Madison Square Christian Reformed Church and the Grand Rapids Chinese Christian church. She enjoys music and worship, traveling,  photography, and playing volleyball and tennis.

Education

  • BS, Drexel University, 1998
  • PhD, John Hopkins University, 2004

Professional Experience

  • Research Assistant, SmithKline Beechem Pharmaceuticals, 1994-1995
  • Research Intern, McNeil Consumer Product Company, 1995-1996
  • Post-doctoral fellow, Johns Hopkins University 2004-2005
  • Adjunct professor of biology, Washington Bible College, 2005
  • Assistant Professor, ÃÛÌÒapp College, 2005-2011
  • Associate Professor, ÃÛÌÒapp College, 2011-2018
  • Professor, ÃÛÌÒapp College 2018-present

Academic Interests

  • T cell immunology
  • Traditional Chinese Medicine.

Research

Dr. Shen's ongoing research studies latent reservoirs of HIV infection. She is investigating the mechanisms of how reservoirs are formed and potential ways to remove the latent reservoir. Her latest work involves investigating the roles of endothelial cells in HIV infection and latency in resting CD4+ T cells. Read more about Professor Shen's .

  • HIV as a Latent Reservoir in Resting T Helper Cells.
  • Investigating the Roles of Endothelial Cells on HIV Infection.

Visit /news/archive/faculty-profile-anding-shen for more information. 

Research and Scholarship

HIV(2)

HIV as a Latent Reservoir in Resting T Helper Cells

<p>Currently, HIV latency is the most significant problem preventing a cure for AIDS. In this study, a replication incompetent pseudotyped virus system is used to investigate how endothelial cells interact with resting T helper cells to promote HIV infection and latency formation.</p>
<p>Student Contributors: Tran Nguyen, Abuoma Nwadike, Wei Wang, John Morris, Anne Barron, John Morris, Yelena Boykov, Jake Baker, Geoff Scott</p>
Investigating Roles of Endothelial Cells on HIV Infection(2)

The Roles of Endothelial Cells on HIV Infection

<p>In many patients with HIV-1 infection, highly active antiretroviral therapy (HAART) successfully suppresses viral loads and restores the immune system. However, a major latent reservoir identified in resting T helper cells (a type of white blood cells) poses a great barrier to viral eradication and ensures viral persistence in patients. A more complete understanding of the mechanisms contributing to the establishment of the reservoir will influence the strategies in battling viral persistence. Some recent studies demonstrated that endothelial cells increased the level of HIV infection in resting T helper cells and might play a significant role in latency formation in these cells. In this study, a replication incompetent pseudotyped virus system is used to investigate how endothelial cells interact with resting T helper cells to promote HIV infection and latency formation.</p>
Anding Shen

Contact Me

526-6025

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